NESBA CryoEM Symposium

NESBA half-day cryoEM symposium focused on Structure Based Drug Discovery and Current Methodology New England Structural Biology Association is hosting a mini-symposium on October 3, 2024 The event will be hosted by Sanofi at Cambridge Crossing and is co-organized and sponsored by Nanoimaging Services with additional sponsorships from Refeyn and Clovertex. Seats will be limited and the audience are scientists who have interest in the day-to-day working of cryoEM data processing, computational structure determination and the rational design of drugs using molecular structures. Agenda 1:30 PM - 2.00 PM Sanofi Structural Biology Team (30 minutes) 2:00 PM - 2:30 PM Structural Optimization for Enhanced TFR Targeted Brain Delivery: Joe Arndt, Biogen (30 minutes) 2:30 PM - 2:50 PM Designing proteasome inhibitors by studying the structure of the endogenous inhibitor PI31/Fub1: Richard Walsh, Harvard Cryo-EM Center for Structural Biology (20 minutes) 2:50 PM - 3:20 PM Structural Virology by cryo-EM: from basic science to translation: Priyamvada Acharya, Duke Center for HIV Structural Biology at Duke University (30 minutes) 3:20 PM - 3:50 PM Break (30 minutes) 3:50 PM - 4:10 PM Understanding the Mechanism of Action with Various Modalities for SBDD: Kevin Huynh, Pfizer (20 minutes) 4:10 PM - 4:30 PM Structure of anellovirus-like particles reveal a mechanism for immune evasion: Rajendra Boggavarapu, Ring Therapeutics (20 minutes) 4:30 PM - 4:50 PM Sink or swim: using cryoEM to understand off-target hERG binding in Drug Discovery: Christine Carbone, Relay Therapeutics (20 minutes) 4:50 PM - 5:10 PM Towards rapid, purification-free structural biology (of ribosomes): Mira May, Massachusetts Institute of Technology (20 minutes) 5:10 PM - 5:30 PM Single particle cryoEM in drug development targeting GPCRs: Ximena Barros-Álvarez, Tectonic Therapeutic (20 minutes) Registration is now closed Hosted by Primary sponsors Sponsors

Thursday, October 3, 2024 Time: 1:30 to 5:30 PM Meeting location Sanofi 450 Water Street Cambridge, MA 02143 Mixer 5:30 - 8:00 PM Geppetto 100 N First Street Cambridge, MA 02141

Previous Meetings

• Cryo-EM Symposium
• NESBA BIO-SAXS Symposia
• A workshop to focus on cryoEM
• A workshop to focus on BIO-SAXS applications in drug discovery
• Targeting RNA: Expanding Therapeutic Biology
• The Resolution Revolution in cryoEM: Potential for Drug Discovery
• Exploiting Genomic Instability in Cancer: DNA Damage and Immuno Oncology
• Future of Drug Delivery: Novel Approaches to Targeted Therapies
• Genome Engineering: Theory into Practice
• Hybrid Methods: The Evolution of Structural Biology
• Protein Misfolding and Rare Genetic Diseases: From Human Genetics to Drug Discovery
• Protein-Ligand Thermodynamics and Kinetics: Building bridges between in silico and biophysical realms
• Assaying Proteins in Solution: A workshop to focus on BIO-SAXS
• Epigenetics: Unwrapping the Future for Drug Discovery?
• Beyond the lattice: A Renaissance In Structural Biology
• Celebrating 50 Years of Crystallography
• Protein Engineering: Techniques and Applications
• New Techniques in Protein Sciences - developments in protein science for biopharma and drug discovery
• Infectious Disease and Drug Discovery Meeting
• Overcoming the Challenges to Accelerate Drug Discovery
• Membrane Proteins: Structure and Function
• Protein Kinases and Drug Discovery
• Systems Biology in Drug Discovery

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