A workshop to focus on BIO-SAXS applications in drug discovery
New England Structural Biology Association (NESBA) presents a half-day workshop focusing on BIO-SAXS applications in drug discovery
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New England Structural Biology Association (NESBA) will co-host an afternoon event focused on Small Angle X-ray Scattering for Biologics (BIO-SAXS), with topics ranging from current use of SAXS in pharmaceutical formulations, practical tips for optimal sample preparation, best-practice data analyses, incorporation of protein X-ray diffraction and NMR data and future directions. Significant advances have been made in instrumentation and there will also be dedicated opportunities to meet with the major BIO-SAXS equipment designers and manufacturers for laboratory-based instruments. Like protein crystallography, SAXS utilizes an intense, well collimated X-ray beam. However, unlike crystallography in which the X-ray beam is diffracted into discrete reflections, SAXS results in a continuous scattering pattern. This pattern is recorded by a 2D detector and analyzed to reveal the size and shape about the macromolecules in solution. Whereas NMR and X-ray crystallography yield high resolution, atomic-level detail, SAXS data are low resolution fingerprints or profiles of solution states. Researchers can learn about the stability and dynamics of a molecule and look at the molecular envelopes of large complexes and complicated biological formulations. Beyond proteins in solution, the technique is applicable to all biological solutions including complex formulations such as lipids, liposomes and nanoparticles. These have seen a recent surge in utility with the advent of nucleic acid and viral drug delivery. This meeting will be the first in a regular "workshop" format intended to share latest use cases and novel applications of BIO-SAXS in the drug discovery industry. Confirmed speakers
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Tuesday, June 28, 2022 12:30 PM – 5:00 PM EDT Meeting locationMassbio Organizing Committee
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