Next Meeting
Targeting RNA: Expanding Therapeutic Biology
New England Structural Biology Association (NESBA) presents a one day conference on The Resolution Revolution in cryoEM: Potential for Drug Discovery.
LaCava Center
Bentley University
Waltham, MA
Friday, September 20, 2019
This symposium will focus on the rapidly evolving field of RNA as a drug target for small molecules. Key areas that will be discussed include; 1) Advances in RNA biology and its role in human disease; 2) Approaches for interrogating relevant RNA and RNA/protein structures; and 3) Strategies for identifying small molecule lead matter for targeting RNA..
Speakers:
 Christopher Burge |  Natalie Dales |  Michelle Hall |  Isaac Kimsey |
 Christopher Lima |  Anna Marie Pyle |  John Schneekloth, Jr. |  Kevin Weeks |
Agenda:
| 8:00-8:50 AM | Registration and light breakfast | |
| 8:50-9:00 AM | Opening remarks: Martin Pettersson (Pfizer) | |
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Session 1: Targeting RNA: Expanding Therapeutic
Biology |
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| 9:00-10:00 | Anna Marie Pyle (Yale University) "RNA Recognition and Activation of the RIG-I Receptor: a Path to Immunomodulatory Therapeutics" |
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| 10:00-10:40 | Christopher Lima (Memorial Sloan Kettering) "Targeting RNA for Degradation by the Eukaryotic RNA Exosome" |
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| 10:40-11:00 | Coffee Break - Sponsored by HitGen Inc | |
| 11:00-11:40 | Michelle Hall (Moderna Therapeutics) "Rational, Structure-based Design of mRNA Therapeutics" |
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| 11:40 – 12:20 | Isaac Kimsey (Nymirum) "Importance of RNA Dynamics in RNA-Targeted Drug Discovery" |
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| 12:20-1:20 | Lunch | |
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Session 2: Targeting RNA: Expanding Therapeutic
Biology |
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| 1:20-2:00 | Kevin Weeks (Ribometrix / University of North Carolina, Chapel Hill) "Structure Based Discovery of New Functions in Large RNAs" |
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| 2:00-2:40 | John Schneekloth, Jr. (NIH) "Targeting Structurally and Functionally Diverse Nucleic Acids with Druglike Small Molecules" |
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| 2:40-3:00 | Coffee Break - Sponsored by HitGen Inc | |
| 3:00-3:40 | Natalie Dales (Novartis) "Discovery of the Splicing Modulator LMI070 for Spinal Muscular Atrophy" |
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| 3:40-4:20 | Christopher Burge (Massachusetts Institute of Technology) "Understanding RNA-binding Protein Function through integration of in Vitro and In Vivo Data" |
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| 4:20-6:30 | Mixer / Networking session | |
Meeting Organizers
- Jeremy Baryza (Vertex)
- Razvan Nutiu (Novartis)
- Martin Pettersson (Pfizer)
Maps, Directions & Lodging Information
Our full-day event will take place at Bentley University. Please click here to find directions and detailed information on area lodging.
Previous Meetings
- The Resolution Revolution in cryoEM: Potential for Drug Discovery
- Exploiting Genomic Instability in Cancer: DNA Damage and Immuno Oncology
- Future of Drug Delivery: Novel Approaches to Targeted Therapies
- Genome Engineering: Theory into Practice
- Hybrid Methods: The Evolution of Structural Biology
- Protein Misfolding and Rare Genetic Diseases: From Human Genetics to Drug Discovery
- Protein-Ligand Thermodynamics and Kinetics: Building bridges between in silico and biophysical realms
- Assaying Proteins in Solution: A workshop to focus on BIO-SAXS
- Epigenetics: Unwrapping the Future for Drug Discovery?
- Beyond the lattice: A Renaissance In Structural Biology
- Celebrating 50 Years of Crystallography
- Protein Engineering: Techniques and Applications
- New Techniques in Protein Sciences - developments in protein science for biopharma and drug discovery
- Infectious Disease and Drug Discovery Meeting
- Overcoming the Challenges to Accelerate Drug Discovery
- Membrane Proteins: Structure and Function
- Protein Kinases and Drug Discovery
- Systems Biology in Drug Discovery