2006 Inaugural NESBA Meeting
Protein Kinases and Drug Discovery
Bentley University
Waltham, MA
March 3, 2006
Keynote Speakers:
Prof. Stephen C. Harrison, Harvard University
Dr. Sandra Jacobs, Novartis (Basel)
and speakers from: Vertex, Amgen, Wyeth, Pfizer, Novartis, Transform
Schedule:
| 8:00 - 9:00 am | An Accelrys Breakfast |
| 9:00 - 9:15 am | Introductory remarks |
| 9:15 - 10:15 am | Keynote Speaker: "Viral fusion proteins as targets for viral entry inhibitors" Professor Stephen C Harrison – Harvard University |
| 10:15 - 10:45 am | "Crystal structures of MEK1 and MEK2: Novel mode of kinase inhibition and implications in drug design" Huifen Chen – Pfizer (Ann Arbor, Michigan) |
| 10:45 - 11:00 am | An IBM coffee break |
| 11:00 - 11:30 am | "Classification of kinase X-ray structures reveals discrete conformations with distinct ligand binding pockets" Brian Hare – Vertex |
| 11:30 - 12:00 am | "Crystallography and Drug Discovery of VEGF Receptor Kinase Inhibitors." Doug Whittington – Amgen |
| 12:00 - 1:00 am | A Rigaku Lunch – "Improving your Pipeline" Joseph Ferrara – Rigaku (12:30 – 1:00) |
| 1:00 - 2:00 am | Keynote Speaker: "What we did to support drug discovery for the Gleevec- follow-up project" Dr Sandra Jacobs – Novartis (Basel) |
| 2:00 - 2:30 am | "The practical challenges of designing Kinase drugs; a modeling perspective" Ian McFadyen – Transform Pharmaceuticals |
| 2:30 - 3:00 am | "The biology of PKCs" Divya Chaudry – Wyeth |
| 3:00 - 3:30 am | A GENEWIZ Coffee break |
| 3:30 - 4:00 am | "Baculovirus expression of protein kinases: Lessons learnt" Ian Hunt – Novartis |
| 4:00 - 4:30 am | "TBD" Ernst ter Haar – Vertex |
| 5:00 - 7:00 am | A Fluidigm Mixer |