Beyond the lattice: A Renaissance In Structural Biology
New England Structural Biology Association (NESBA) presents a one day conference on Protein Misfolding and Rare Genetic Diseases: From Human Genetics to Drug Discovery
LaCava Center
Bentley University
Waltham, MA
February 25, 2011
8:00 am - 5:30 pm
This one-day symposium discussed the power of "low resolution" structural biology tools and the impact of these tools on the future of structural biology. It was also intended to promote interactions and collaboration among industrial and academic groups. Steve Harrison gave an introduction and David Derosier provided a historical and personal perspective on 3-D image reconstruction. Speakers included Niko Grigorieff, Debbie Kelly, Andres Leschziner, Chris Akey, Tim Baker, Daniela Nicastro, Fred Sigworth, John Tainer, Marcelo Berardi, and Xiaowei Zhuang.
Schedule:
8:00 - 9:00 am Light breakfast, registration, and poster / exhibitor setup
9:00 - 9:30 am Steve Harrison (Introduction) (Harvard Medical School)
Session I
9:30 - 10:00 am David DeRosier
"3D Reconstruction from
Electron Micrographs: A Personal Account of its Development" (Brandeis
University)
10:00 - 10:35 am Niko Grigorieff
"Image Processing Methods for
High-Resolution Cryo-EM" (Brandeis University)
10:35 - 10:55 am Coffee break, poster session
10:55 - 11:30 am Debbie Kelly
"Affinity Grid
applications for cryo-EM" (Virginia Tech Carilion Research Institute)
11:30 - 12:05 pm Andres Leschziner
"The challenge of obtaining initial
models for novel, asymmetric macromolecules in EM" (Harvard
University)
12:05 - 12:40 pm Christopher Akey "Structure and Function of
Apoptosomes" (Boston University School of Medicine)
12:40 - 1:40 pm Lunch
Session II
1:40 - 2:15 pm Tim Baker
"Three-dimensional
Reconstructions of Tailed Bacteriophage: Past, Present, and Future"
(University of California, San Diego)
2:15 - 2:50 pm Daniela Nicastro
"Deconstructing Cilia and Flagella
Function with Cryo-Electron Tomography and Structural Proteomics" (Brandeis
University)
2:50 - 3:25 pm Fred Sigworth
"Random spherically-constrained
reconstruction of membrane proteins as single particles" (Yale University)
3:25 - 3:45 pm Snack break, poster session
Session III
3:45 - 4:20 pm John Tainer
"Accurate macromolecular
structures, conformations, and assemblies in solution by combined X-ray
scattering (SAXS) and crystallography" (Scripps Research Institute)
4:20 - 4:55 pm Xiaowei Zhuang
"Sub-diffraction imaging with STORM"
(Harvard University)
4:55 - 5:30 pm Marcelo Berardi
"Piecing together molecular fragments:
Structure of UCP2 determined by residual dipolar coupling search and topological
constraints" (Harvard Medical School)
5:30 pm Mixer and poster session (Beer, wine and soft drinks)
Meeting Organizers:
- Jim Griffith, Vertex
- John Diener, Novartis
- Junhua Pan, Harvard Medical School
Meeting Sponsors:
- Emmanuel College
- Formulatrix
- Genewiz
- JEOL
- Microlytic
- Rigaku