Hybrid Methods: The Evolution of Structural Biology

New England Structural Biology Association (NESBA) presents a one day conference on Hybrid Methods: The Evolution of Structural Biology

LaCava Center
Bentley University
Waltham, MA 
Friday, October 4, 2013 
8:00 am - 6:00 pm

The complexity and scale of problems that can now be tackled by structural biology labs is ever increasing. A powerful approach that has emerged in modern structural biology is the application of multiple complimentary techniques. This paints a more complete picture of a biological process. The goal of this NESBA meeting entitled 'Hybrid Methods: The Evolution of Structural Biology" is to show how these diverse and complimentary techniques can be blended. We have assembled an outstanding lineup of accomplished scientists from academia and industry to provide the best examples in our community.


8:00-8:45 am: Check-in and light breakfast

8:45 - 9:00 am: Opening remarks: Raj Chopra - NESBA

9:00 - 9:45 am: "Crystals as Industrial Materials and Catalysts" 
Manuel Navia - Executive-in-Residence at Oxford Bioscience Partners

Session 1
Morning Session Chair: Michael Murray

9:45 - 10:30 am: "The dynamic personality of enzymes -from kinase dynamics during catalysis to Gleevec's selectivity" 
Dorothee Kern - Professor of Biochemistry and HHMI Investigator, Brandeis University

10:30 - 11:00 am: Morning Break

11:00 - 11:45 am: "Building a new machine from ancient parts: how Nature transformed a helicase motor into a family of biosensors for innate immunity" 
Anna Marie Pyle - Professor Departments of Molecular, Cellular and Developmental Biology and Department of Chemistry, HHMI Investigator, Yale University

11:45 - 12:30 pm: "Hybrids Approaches in Electron Microscopy" 
Claudio Ciferri - Novartis Vaccines and Diagnostics

12:30 - 1:30 am: Lunch

Session 2 
Afternoon Session Chair: Matthew Calabrese

1:30 - 2:15 pm: "The dynamic nature of mitochondrial uncoupling proteins" 
James Chou - Professor Biological Chemistry & Molecular Pharmacology, Harvard Medical School

2:15 - 3:00 pm: "Combating Drug Resistance: Lessons From the viral proteases of HIV-1 and HCV" 
Celia Schiffer - Professor Department of Biochemistry & Molecular Pharmacology, UMass Medical School

3:00 - 3:20 pm: Afternoon break

3:20 - 4:05 pm: "Structural and functional assessment of bacterial immunophillins as potential targets for broad-spectrum antibiotic lead discovery" 
Don Lorimer - Emerald Bio

4:05 - 4:50 pm: "Presenting viral envelope glycoproteins on rotavirus" 
Junhua Pan - Postdoctoral fellow in the lab of Stephen Harrison, Harvard Medical School

4:50 - 6:30 pm: Cocktail / Social hour

Meeting Organizers:

Meeting Sponsors:

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