Genome Engineering: Theory into Practice

New England Structural Biology Association (NESBA) presents a one day conference on Genome Engineering: Theory into Practice

LaCava Center
Bentley University
Waltham, MA 
Friday, June 20, 2014 
8:00 am - 6:00 pm

We will be exploring the scientific basis of zinc-finger nuclease, TALEN and CRISPR gene-editing technologies. In particular, their application to cell engineering to build disease models, animal models and potential applications to the clinic.

The goal of this NESBA meeting entitled 'Genome engineering: Theory into Practice' is to show how these techniques can be exploited for research and medical applications. Our volunteer organizers have assembled an outstanding lineup of accomplished scientists from academia and industry to provide the best examples in our community.


8:00-8:45 am Check-in and light breakfast
8:45-9:00 am Opening remarks: Raj Chopra-NESBA

Session 1 - Morning
Session Chair: Zehan Abdul-Manan

9:00-9:45 am DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
Sam Sternberg, Lab of Jennifer Doudna, UC Berkeley
9:45-10:30 am Genome-wide CRISPR-Cas9 functional genetic screens in human cells
Neville Sanjana, Simons Postdoctoral Fellow, Broad Institute of Harvard & MIT
10:30-11:00 am Morning Break
11:00-11:45 am Scalable Platforms for Synthetic Biology in Human Cells
Timothy K. Lu, MIT Synthetic Biology Center
11:45-12:30 pm Genome editing for disease modeling and treatment
Qiurong Ding, Postdoctoral Fellow, Dept of Stem Cell and Regenerative Biology, Harvard University
12:30-1:30 pm Lunch

Session 2 - Afternoon
Session Chair: Brad Guild

1:30-2:15 pm

Rodent genome engineering using ZFNs and CRISPR/Cas9
Xiaoxia Cui, VP of Research and Development, Sage Labs, Inc.

2:15-3:00 pm Defining and Improving the Specificities of Genome-editing CRISPR-Cas Nucleases
Keith Joung, MGH/Harvard Medical School
3:00-3:20 pm Afternoon break
3:20-4:05 pm Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype 
Hao Yin, Postdoctoral, David H. Koch Institute for Integrative Cancer Research, MIT
4:05-5:00 pm Keynote Speaker New Approaches, Analytics and Applications of Genome Engineering
George Church, Professor, Harvard Medical School
4:50-6:30 pm Cocktail / Social hour

Meeting Organizers:

Meeting Sponsors:

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