Protein Engineering: Techniques and Applications

Bentley University
Waltham, MA 
Tuesday, May 19, 2009 


8:00-9:00 am Check-in and light breakfast
9:00-9:05 am Opening Remarks, Marc Jacobs, Vertex Pharmaceuticals
Session I: Engineering for affinity and specificity (Session chair: Laura Silvian)
9:05-10:00 am Synthetic Antibodies: New Tools for New Biology
Sachdev Sidhu, University of Toronto, Toronto, Canada
10:00-10:35 am Engineered Variant of Human Artemin with Reduced Heparin Sulfate Binding has Improved Pharmaceutical Properties
Anthony Rossomando, Biogen Idec, Cambridge, MA
10:35-10:55 am Coffee break and poster session
10:55-11:50 am Design and construction of a highly functional, non-random, synthetic
pre-immune antibody repertoire

Dane Wittrup, Adimab, Inc., Lebanon, NH
11:50-12:40 pm Lunch
Session II: Alternative scaffolds (Session chair: Ben Hackel)
12:40-1:35 pm Beyond Antibodies: Designer binding proteins using non-antibody scaffolds
Shohei Koide, University of Chicago, Chicago, IL
1:35-2:05 pm Dual Variable Domain Immunoglobulin (DVD-Ig)
Chengbin Wu, Abbott Bioresearch Center, Worcester, MA
2:05-2:35 pm The Evolution of Molecular Diversity in β-Bundles
Jessica Goodman, Schepartz Laboratory, Yale University
2:35-3:00 pm Coffee break and poster session
Session III: Ligands and enzyme engineering (Session chair: Joe Arndt)
3:00-3:55 pm Role of Electrostatics in Ligand Binding and Design
Bruce Tidor, Massachusetts Institute of Technology, Cambridge, MA
3:55-4:25 pm Quantitative Exploration of Catalytic Landscapes in Protein Evolution
Paul O'Maille, The Salk Institute for Biological Sciences, La Jolla, CA
4:25-4:55 pm Engineering enzyme substrate specificity using computational design of a defined-sequence library
Shaun Lippow, Codon Devices
4:55 pm-onward Mixer and poster session

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