2006 Inaugural NESBA Meeting
Protein Kinases and Drug Discovery

Bentley University
Waltham, MA 
March 3, 2006

Keynote Speakers:

Prof. Stephen C. Harrison, Harvard University
Dr. Sandra Jacobs, Novartis (Basel)
and speakers from: Vertex, Amgen, Wyeth, Pfizer, Novartis, Transform

Schedule:

8:00 - 9:00 am An Accelrys Breakfast
9:00 - 9:15 am Introductory remarks
9:15 - 10:15 am Keynote Speaker: "Viral fusion proteins as targets for viral entry inhibitors"
Professor Stephen C Harrison – Harvard University
10:15 - 10:45 am "Crystal structures of MEK1 and MEK2: Novel mode of kinase inhibition and implications in drug design"
Huifen Chen – Pfizer (Ann Arbor, Michigan)
10:45 - 11:00 am An IBM coffee break
11:00 - 11:30 am "Classification of kinase X-ray structures reveals discrete conformations with distinct ligand binding pockets"
Brian Hare – Vertex
11:30 - 12:00 am "Crystallography and Drug Discovery of VEGF Receptor Kinase Inhibitors."
Doug Whittington – Amgen
12:00 - 1:00 am A Rigaku Lunch – "Improving your Pipeline"
Joseph Ferrara – Rigaku (12:30 – 1:00)
1:00 - 2:00 am Keynote Speaker: "What we did to support drug discovery for the Gleevec- follow-up project"
Dr Sandra Jacobs – Novartis (Basel)
2:00 - 2:30 am "The practical challenges of designing Kinase drugs; a modeling perspective"
Ian McFadyen – Transform Pharmaceuticals
2:30 - 3:00 am "The biology of PKCs"
Divya Chaudry – Wyeth
3:00 - 3:30 am A GENEWIZ Coffee break
3:30 - 4:00 am "Baculovirus expression of protein kinases: Lessons learnt"
Ian Hunt – Novartis
4:00 - 4:30 am "TBD"
Ernst ter Haar – Vertex
5:00 - 7:00 am A Fluidigm Mixer


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