Beyond the lattice: A Renaissance In Structural Biology

New England Structural Biology Association (NESBA) presents a one day conference on Protein Misfolding and Rare Genetic Diseases: From Human Genetics to Drug Discovery

LaCava Center
Bentley University
Waltham, MA 
February 25, 2011 
8:00 am - 5:30 pm

This one-day symposium discussed the power of "low resolution" structural biology tools and the impact of these tools on the future of structural biology. It was also intended to promote interactions and collaboration among industrial and academic groups. Steve Harrison gave an introduction and David Derosier provided a historical and personal perspective on 3-D image reconstruction. Speakers included Niko Grigorieff, Debbie Kelly, Andres Leschziner, Chris Akey, Tim Baker, Daniela Nicastro, Fred Sigworth, John Tainer, Marcelo Berardi, and Xiaowei Zhuang.


8:00 - 9:00 am  Light breakfast, registration, and poster / exhibitor setup

9:00 - 9:30 am   Steve Harrison (Introduction) (Harvard Medical School)

Session I

9:30 - 10:00 am  David DeRosier
"3D Reconstruction from Electron Micrographs: A Personal Account of its Development" (Brandeis University)
10:00 - 10:35 am  Niko Grigorieff
"Image Processing Methods for High-Resolution Cryo-EM" (Brandeis University)

10:35 - 10:55 am  Coffee break, poster session

10:55 - 11:30 am  Debbie Kelly
"Affinity Grid applications for cryo-EM" (Virginia Tech Carilion Research Institute)
11:30 - 12:05 pm  Andres Leschziner
"The challenge of obtaining initial models for novel, asymmetric macromolecules in EM" (Harvard University)
12:05 - 12:40 pm  Christopher Akey "Structure and Function of Apoptosomes" (Boston University School of Medicine)

12:40 - 1:40 pm  Lunch

Session II

1:40 - 2:15 pm  Tim Baker
"Three-dimensional Reconstructions of Tailed Bacteriophage: Past, Present, and Future" (University of California, San Diego)
2:15 - 2:50 pm  Daniela Nicastro
"Deconstructing Cilia and Flagella Function with Cryo-Electron Tomography and Structural Proteomics" (Brandeis University)
2:50 - 3:25 pm  Fred Sigworth
"Random spherically-constrained reconstruction of membrane proteins as single particles" (Yale University)

3:25 - 3:45 pm  Snack break, poster session

Session III

3:45 - 4:20 pm  John Tainer
"Accurate macromolecular structures, conformations, and assemblies in solution by combined X-ray scattering (SAXS) and crystallography" (Scripps Research Institute)
4:20 - 4:55 pm  Xiaowei Zhuang
"Sub-diffraction imaging with STORM" (Harvard University)
4:55 - 5:30 pm  Marcelo Berardi
"Piecing together molecular fragments: Structure of UCP2 determined by residual dipolar coupling search and topological constraints" (Harvard Medical School)

5:30 pm  Mixer and poster session (Beer, wine and soft drinks)

Meeting Organizers:

Meeting Sponsors:

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